{"id":10524,"date":"2026-06-04T22:36:47","date_gmt":"2026-06-04T19:36:47","guid":{"rendered":"https:\/\/dbsnewsmedia.com\/?p=10524"},"modified":"2026-06-04T22:36:47","modified_gmt":"2026-06-04T19:36:47","slug":"kanserin-gizlenme-mekanizmasi-cokertildi-cigir-acan-ilactan-ilk-sonuclar","status":"publish","type":"post","link":"https:\/\/dbsnewsmedia.com\/?p=10524","title":{"rendered":"Kanserin Gizlenme Mekanizmas\u0131 \u00c7\u00f6kertildi: \u00c7\u0131\u011f\u0131r A\u00e7an \u0130la\u00e7tan \u0130lk Sonu\u00e7lar"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">04.06.2026    22:37<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kanser h\u00fccrelerinin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden saklanmas\u0131n\u0131 engelleyen yeni nesil bir ak\u0131ll\u0131 ila\u00e7, onkoloji d\u00fcnyas\u0131nda b\u00fcy\u00fck heyecan yaratt\u0131. \u0130ngiltere\u2019deki Oxford \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131 taraf\u0131ndan geli\u015ftirilen deneysel tedavi, daha \u00f6nce mevcut y\u00f6ntemlere yan\u0131t vermeyen ileri evre hastalarda t\u00fcm\u00f6rlerin k\u00fc\u00e7\u00fclmesini sa\u011flayarak dikkat \u00e7ekici sonu\u00e7lar ortaya koydu.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">D\u00fcnyan\u0131n En B\u00fcy\u00fck Kanser Kongresinde A\u00e7\u0131kland\u0131<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rman\u0131n ilk klinik sonu\u00e7lar\u0131, ABD\u2019nin Chicago kentinde d\u00fczenlenen ve d\u00fcnyan\u0131n en \u00f6nemli onkoloji etkinliklerinden biri kabul edilen Amerikan Klinik Onkoloji Derne\u011fi (ASCO) Kongresi\u2019nde payla\u015f\u0131ld\u0131.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0130ngiltere, Fransa, \u0130spanya ve Avustralya\u2019da y\u00fcr\u00fct\u00fclen Faz 1 klinik \u00e7al\u0131\u015fmas\u0131na; akci\u011fer, ba\u011f\u0131rsak, karaci\u011fer, mesane, rahim a\u011fz\u0131 ile ba\u015f-boyun kanseri tan\u0131s\u0131 bulunan toplam 83 hasta kat\u0131ld\u0131. \u00c7al\u0131\u015fmaya dahil edilen hastalar\u0131n tamam\u0131n\u0131n daha \u00f6nce uygulanan standart tedavilere yan\u0131t vermedi\u011fi belirtildi.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">T\u00fcm\u00f6rlerde Belirgin K\u00fc\u00e7\u00fclme Sa\u011flad\u0131<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rmada \u201cGRWD5769\u201d isimli deneysel ila\u00e7, mevcut imm\u00fcnoterapi ila\u00e7lar\u0131ndan biri olan cemiplimab ile birlikte kullan\u0131ld\u0131.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Elde edilen sonu\u00e7lara g\u00f6re 26 hastada t\u00fcm\u00f6rlerin k\u00fc\u00e7\u00fcld\u00fc\u011f\u00fc g\u00f6zlenirken, 15 hastada t\u00fcm\u00f6r boyutlar\u0131nda en az y\u00fczde 30 oran\u0131nda gerileme kaydedildi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca tedavinin baz\u0131 kanser t\u00fcrlerinde hastal\u0131\u011f\u0131n ilerlemesini en az alt\u0131 ay boyunca durdurabildi\u011fini bildirdi. Buna g\u00f6re;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Akci\u011fer kanserinde y\u00fczde 55,<\/li>\n\n\n\n<li>Ba\u011f\u0131rsak kanserinde y\u00fczde 51,<\/li>\n\n\n\n<li>Ba\u015f ve boyun kanserlerinde y\u00fczde 38,<\/li>\n\n\n\n<li>Mesane kanserinde y\u00fczde 36,<\/li>\n\n\n\n<li>Karaci\u011fer kanserinde y\u00fczde 32,<\/li>\n\n\n\n<li>Rahim a\u011fz\u0131 kanserinde ise y\u00fczde 18 oran\u0131nda hastal\u0131k kontrol\u00fc sa\u011fland\u0131.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Kanserin \u201cG\u00f6r\u00fcnmezlik Kalkan\u0131n\u0131\u201d Hedefliyor<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Uzmanlara g\u00f6re kanser h\u00fccreleri, ERAP1 ad\u0131 verilen bir enzimi kullanarak ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden gizlenebiliyor. Bu durum, imm\u00fcnoterapi tedavilerinin \u00f6nemli bir b\u00f6l\u00fcm\u00fcn\u00fcn ba\u015far\u0131s\u0131z olmas\u0131n\u0131n ba\u015fl\u0131ca nedenlerinden biri olarak g\u00f6r\u00fcl\u00fcyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Yeni geli\u015ftirilen GRWD5769 ise bu enzimi bask\u0131layarak kanser h\u00fccrelerinin ba\u011f\u0131\u015f\u0131kl\u0131k sistemi taraf\u0131ndan yeniden tan\u0131nmas\u0131n\u0131 sa\u011fl\u0131yor. B\u00f6ylece T h\u00fccreleri t\u00fcm\u00f6rleri hedef alabiliyor ve imm\u00fcnoterapinin etkinli\u011fi art\u0131r\u0131labiliyor.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Uzmanlardan Temkinli \u0130yimserlik<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c7al\u0131\u015fman\u0131n ba\u015f ara\u015ft\u0131rmac\u0131lar\u0131ndan Prof. Fiona Thistlethwaite, ilac\u0131n hen\u00fcz erken a\u015famada olmas\u0131na ra\u011fmen elde edilen sonu\u00e7lar\u0131n olduk\u00e7a umut verici oldu\u011funu belirtti. Hap formunda kullan\u0131lan tedavinin hastalar taraf\u0131ndan genel olarak iyi tolere edildi\u011fi ifade edildi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ara\u015ft\u0131rmac\u0131lar, elde edilen bulgular\u0131n kanser tedavisinde yeni bir yakla\u015f\u0131m\u0131n kap\u0131s\u0131n\u0131 aralayabilece\u011fini ancak y\u00f6ntemin etkinli\u011finin ve uzun vadeli sonu\u00e7lar\u0131n\u0131n do\u011frulanmas\u0131 i\u00e7in daha geni\u015f kapsaml\u0131 klinik \u00e7al\u0131\u015fmalara ihtiya\u00e7 duyuldu\u011funu vurgulad\u0131.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Yeni Faz \u00c7al\u0131\u015fmalar\u0131 Planlan\u0131yor<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0130lac\u0131 geli\u015ftiren biyoteknoloji \u015firketi, daha b\u00fcy\u00fck hasta gruplar\u0131n\u0131 kapsayacak yeni klinik \u00e7al\u0131\u015fmalar\u0131n haz\u0131rl\u0131klar\u0131na ba\u015flad\u0131\u011f\u0131n\u0131 a\u00e7\u0131klad\u0131. Uzmanlar, ilerleyen s\u00fcre\u00e7te olumlu sonu\u00e7lar\u0131n devam etmesi halinde bu yakla\u015f\u0131m\u0131n \u00f6zellikle tedavi se\u00e7enekleri t\u00fckenmi\u015f ileri evre kanser hastalar\u0131 i\u00e7in \u00f6nemli bir alternatif olu\u015fturabilece\u011fini de\u011ferlendiriyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Karde\u015f haber kaynak:<a href=\"https:\/\/radarhabermedya.com\/2026\/06\/04\/kanserin-gizlenme-mekanizmasi-cokertildi-cigir-acan-ilactan-ilk-sonuclar\/\">https:\/\/radarhabermedya.com\/2026\/06\/04\/kanserin-gizlenme-mekanizmasi-cokertildi-cigir-acan-ilactan-ilk-sonuclar\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kaynak:&nbsp;<a href=\"https:\/\/www.cumhuriyet.com.tr\/saglik\/tip-dunyasinda-devrim-akilli-ilac-kanserin-gorunmezlik-kalkanini-yikti-tumorleri-yuzde-30-kuculttu-2509257\">https:\/\/www.cumhuriyet.com.tr\/saglik\/tip-dunyasinda-devrim-akilli-ilac-kanserin-gorunmezlik-kalkanini-yikti-tumorleri-yuzde-30-kuculttu-2509257<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">04.06.2026 \u2013 18:06<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>04.06.2026 22:37 Kanser h\u00fccrelerinin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminden saklanmas\u0131n\u0131 engelleyen yeni nesil bir ak\u0131ll\u0131 ila\u00e7, onkoloji d\u00fcnyas\u0131nda b\u00fcy\u00fck heyecan yaratt\u0131. \u0130ngiltere\u2019deki Oxford \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131 taraf\u0131ndan geli\u015ftirilen deneysel tedavi, daha \u00f6nce mevcut y\u00f6ntemlere yan\u0131t vermeyen ileri evre hastalarda t\u00fcm\u00f6rlerin k\u00fc\u00e7\u00fclmesini sa\u011flayarak dikkat \u00e7ekici sonu\u00e7lar ortaya koydu. D\u00fcnyan\u0131n En B\u00fcy\u00fck Kanser Kongresinde A\u00e7\u0131kland\u0131 Ara\u015ft\u0131rman\u0131n ilk klinik sonu\u00e7lar\u0131, ABD\u2019nin Chicago&#8230;<\/p>\n","protected":false},"author":5,"featured_media":10525,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[12],"tags":[256],"class_list":["post-10524","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-kanser"],"jetpack_featured_media_url":"https:\/\/dbsnewsmedia.com\/wp-content\/uploads\/2026\/06\/image-135.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/10524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10524"}],"version-history":[{"count":1,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/10524\/revisions"}],"predecessor-version":[{"id":10526,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/10524\/revisions\/10526"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/media\/10525"}],"wp:attachment":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}