{"id":2691,"date":"2026-03-14T18:54:16","date_gmt":"2026-03-14T15:54:16","guid":{"rendered":"https:\/\/dbsnewsmedia.com\/?p=2691"},"modified":"2026-03-14T18:54:16","modified_gmt":"2026-03-14T15:54:16","slug":"bilim-dunyasindan-carpici-gelisme-genclerde-hizla-artan-kanser-turune-karsi-yeni-bir-tedavi-bulundu-uzmanlar-umutlu-kanser-tarih-mi-oluyor","status":"publish","type":"post","link":"https:\/\/dbsnewsmedia.com\/?p=2691","title":{"rendered":"Bilim d\u00fcnyas\u0131ndan \u00e7arp\u0131c\u0131 geli\u015fme! Gen\u00e7lerde h\u0131zla artan kanser t\u00fcr\u00fcne kar\u015f\u0131 yeni bir tedavi bulundu. Uzmanlar umutlu: Kanser tarih mi oluyor?"},"content":{"rendered":"\n

Mart ay\u0131, d\u00fcnya genelinde Kolon Kanseri Fark\u0131ndal\u0131k Ay\u0131 olarak kabul ediliyor. \u00d6zellikle gen\u00e7ler aras\u0131nda giderek yayg\u0131nla\u015fan kolon kanseri \u00e7o\u011fu zaman sinsi ilerleyerek \u00f6l\u00fcmc\u00fcl olabiliyor.<\/strong> Ancak G\u00fcney Koreli bilim insanlar\u0131n\u0131n yapt\u0131\u011f\u0131 yeni bir ara\u015ft\u0131rma umut verdi. Ara\u015ft\u0131rmaya g\u00f6re, h\u00fccrelerdeki tek bir proteinin bloke edilmesi kolorektal (kal\u0131n ba\u011f\u0131rsak) kanserinin ilerlemesini durdurabilir ve ya\u015fam s\u00fcresini uzatabilir. \u0130\u015fte dikkat \u00e7eken ara\u015ft\u0131rman\u0131n detaylar\u0131\u2026<\/strong><\/p>\n\n\n\n

Ara\u015ft\u0131rman\u0131n Merkezinde Yer Alan Protein: NSMF<\/strong><\/p>\n\n\n\n

Ulsan Ulusal Bilim ve Teknoloji Enstit\u00fcs\u00fc (UNIST) ara\u015ft\u0131rmac\u0131lar\u0131, NSMF adl\u0131 bir genin (ve \u00fcretti\u011fi proteinin) kanser h\u00fccrelerinin h\u0131zla b\u00f6l\u00fcnmesine ve hayatta kalmas\u0131na yard\u0131mc\u0131 oldu\u011funu saptad\u0131.<\/p>\n\n\n\n

NSMF geni devre d\u0131\u015f\u0131 b\u0131rak\u0131ld\u0131\u011f\u0131nda, kanser h\u00fccreleri b\u00f6l\u00fcnmeye devam edemiyor ve \u2018geri d\u00f6n\u00fclemez h\u00fccresel ya\u015flanma\u2019<\/strong> s\u00fcrecine giriyor.<\/p>\n\n\n\n

Geleneksel kemoterapinin aksine, bu y\u00f6ntemin sa\u011fl\u0131kl\u0131 ba\u011f\u0131rsak h\u00fccrelerine zarar vermedi\u011fi g\u00f6zlemlendi. Bu durum, yan etkilerin \u00e7ok daha az olabilece\u011fi anlam\u0131na geliyor.<\/p>\n\n\n\n

Ara\u015ft\u0131rma Sonu\u00e7lar\u0131 A\u00e7\u0131kland\u0131: Hastalar\u0131n Ya\u015fam S\u00fcresi %33,5 Artt\u0131<\/strong><\/p>\n\n\n\n

Laboratuvar ve fareler \u00fczerinde yap\u0131lan deneylerde \u00e7arp\u0131c\u0131 sonu\u00e7lar elde edildi:<\/p>\n\n\n\n

T\u00fcm\u00f6r kontrol\u00fc:<\/strong><\/em> NSMF geni \u00e7\u0131kar\u0131lan farelerde ba\u011f\u0131rsak t\u00fcm\u00f6r\u00fc olu\u015fumu \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131.<\/p>\n\n\n\n

Ya\u015fam s\u00fcresi:<\/strong> <\/em>Geni devre d\u0131\u015f\u0131 b\u0131rak\u0131lan fareler, bu genin aktif oldu\u011fu farelere k\u0131yasla ortalama y\u00fczde 33,5 oran\u0131nda daha uzun ya\u015fad\u0131.<\/p>\n\n\n\n

H\u00fccresel etki:<\/strong> <\/em>Protein bloke edildi\u011finde t\u00fcm\u00f6r b\u00fcy\u00fcmesi yava\u015flad\u0131 veya tamamen durdu, ancak kanserin tamamen ortadan kalkmad\u0131\u011f\u0131 da not edildi.<\/p>\n\n\n\n

\"Bilim<\/figure>\n\n\n\n

Deneylerde Kritik Bulgular: T\u00fcm\u00f6r\u00fcn B\u00fcy\u00fcme H\u0131z\u0131 Azald\u0131<\/strong><\/strong><\/p>\n\n\n\n

\u201cBilim insanlar\u0131 kolon kanserinde h\u00fccrelerin hayatta kalmas\u0131n\u0131 sa\u011flayan bir proteini tan\u0131mlad\u0131. NSMF adl\u0131 bu protein, kanser h\u00fccrelerinin \u00e7o\u011fal\u0131rken ya\u015fad\u0131\u011f\u0131 DNA stresini y\u00f6netmelerine yard\u0131mc\u0131 oluyor. \u00c7al\u0131\u015fma sayg\u0131n bilim dergilerinden Nucleic Acids Research\u2019te yay\u0131mland\u0131\u201d diyen T\u0131bbi Onkoloji Uzman\u0131 Do\u00e7. Dr. Ay\u015fe \u0130rem Yasin<\/strong>, \u00e7al\u0131\u015fmayla ilgili \u015fu detaylar\u0131 verdi:<\/p>\n\n\n\n

— <\/strong>Kanser h\u00fccreleri \u00e7ok h\u0131zl\u0131 b\u00f6l\u00fcn\u00fcr. Bu h\u0131z s\u0131ras\u0131nda DNA kopyalan\u0131rken hatalar ve zorlanmalar ortaya \u00e7\u0131kar. Buna \u201creplikasyon stresi\u201d diyoruz. Normal \u015fartlarda bu stres h\u00fccreyi durdurabilir ya da \u00f6l\u00fcm\u00fcne yol a\u00e7abilir.<\/p>\n\n\n\n

—<\/strong> Ara\u015ft\u0131rmaya g\u00f6re NSMF proteini, kanser h\u00fccrelerini bu stresten koruyor. Yani h\u00fccrelerin DNA hasar\u0131n\u0131 tolere etmesine yard\u0131mc\u0131 oluyor ve b\u00f6ylece t\u00fcm\u00f6r b\u00fcy\u00fcmeye devam edebiliyor.<\/strong><\/p>\n\n\n\n

—<\/strong> Deneysel modellerde NSMF bask\u0131land\u0131\u011f\u0131nda kanser h\u00fccrelerinde DNA hasar\u0131 artt\u0131 ve t\u00fcm\u00f6r b\u00fcy\u00fcmesi yava\u015flad\u0131. \u00dcstelik normal h\u00fccrelerde belirgin bir zarar g\u00f6zlenmedi. Bu da onu potansiyel bir tedavi hedefi haline getiriyor.<\/p>\n\n\n\n

Bu Ke\u015fif Kanser Tedavisi \u0130\u00e7in Ne \u0130fade Ediyor?<\/strong><\/strong><\/p>\n\n\n\n

\u00c7al\u0131\u015fman\u0131n liderlerinden Dr. Kyeong Jin Shin, NSMF’nin umut verici bir hedef oldu\u011funu ve kanser h\u00fccrelerinde kal\u0131c\u0131 ya\u015flanma yaratarak t\u00fcm\u00f6r b\u00fcy\u00fcmesini durdurabileceklerini belirtti.<\/p>\n\n\n\n

Profes\u00f6r Young Chan Chae ise, \u201cBu proteine kar\u015f\u0131 inhibit\u00f6rler geli\u015ftirmek, kanser h\u00fccrelerinin do\u011fal olarak ya\u015flan\u0131p \u00f6lmesini sa\u011flayan yepyeni bir tedavi yolu sunabilir\u201d diye konu\u015ftu.<\/p>\n\n\n\n

Do\u00e7. Dr. Ay\u015fe \u0130rem Yasin, \u201cHen\u00fcz erken a\u015famada bir ara\u015ft\u0131rma. Ancak gelecekte NSMF\u2019yi hedefleyen ila\u00e7lar geli\u015ftirilirse, kanser h\u00fccrelerinin kendi \u201czay\u0131f noktas\u0131\u201d kullan\u0131labilir. Yani h\u00fccrelerin h\u0131zl\u0131 \u00e7o\u011falma s\u0131ras\u0131nda ya\u015fad\u0131\u011f\u0131 stres onlar\u0131n aleyhine \u00e7evrilebilir\u201d dedi ve ekledi:<\/p>\n\n\n\n

\u201cBu hemen klinik uygulamaya ge\u00e7ecek bir geli\u015fme de\u011fil, bu temel bilim \u00e7al\u0131\u015fmas\u0131. Klinik uygulamaya ge\u00e7ebilmesi i\u00e7in daha fazla ara\u015ft\u0131rma ve insan \u00e7al\u0131\u015fmalar\u0131 gerekiyor. Ancak kolon kanserinde yeni tedavi stratejileri a\u00e7\u0131s\u0131ndan umut verici bir ad\u0131m.\u201d<\/p>\n\n\n\n

Ara\u015ft\u0131rma \u015fu an i\u00e7in bir \u2018ilk ad\u0131m\u2019 niteli\u011finde. Bilim insanlar\u0131, bu genin insanlarda g\u00fcvenli bir \u015fekilde nas\u0131l kapat\u0131labilece\u011fi \u00fczerinde \u00e7al\u0131\u015fmaya devam edecek.<\/p>\n\n\n\n

\"Bilim<\/figure>\n\n\n\n

Uzmanlar Uyar\u0131yor: T\u00fcrkiye\u2019de Kolon Kanseri Gen\u00e7lerde Art\u0131yor mu?<\/strong><\/strong><\/p>\n\n\n\n

Kolorektal kanser, T\u00fcrkiye\u2019de en s\u0131k g\u00f6r\u00fclen kanserler aras\u0131nda ilk \u00fc\u00e7te yer al\u0131yor. Uluslararas\u0131 Kanser Ara\u015ft\u0131rmalar\u0131 Ajans\u0131\u2019n\u0131n (IARC) 2022 verilerine g\u00f6re \u00fclkemizde y\u0131lda yakla\u015f\u0131k 21 bin 700 yeni kolorektal kanser vakas\u0131<\/strong> tan\u0131 al\u0131yor. Ayn\u0131 y\u0131l yakla\u015f\u0131k 11 bin 700 ki\u015fi<\/strong> bu hastal\u0131k nedeniyle hayat\u0131n\u0131 kaybetti.<\/p>\n\n\n\n

Bu da bize \u015funu g\u00f6steriyor: Kolorektal kanser hem g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 hem de \u00f6l\u00fcm oran\u0131 a\u00e7\u0131s\u0131ndan ciddi bir halk sa\u011fl\u0131\u011f\u0131 sorunu.<\/p>\n\n\n\n

\u201c<\/strong>D\u00fcnya genelinde 50 ya\u015f alt\u0131 kolorektal kanser vakalar\u0131nda art\u0131\u015f oldu\u011fu bilimsel olarak g\u00f6sterildi. Bu nedenle art\u0131k Avrupa ve ABD \u2018de kolon kanseri<\/a> tarama programlar\u0131 45 ya\u015f\u0131nda ba\u015flat\u0131l\u0131yor. T\u00fcrkiye\u2019de de klinik g\u00f6zlemler bu e\u011filimle paralel\u201d diyen Do\u00e7. Dr. Ay\u015fe \u0130rem Yasin \u015funlar\u0131 s\u00f6yledi:<\/p>\n\n\n\n

\u201cAncak \u2018gen\u00e7lerde y\u00fczde \u015fu kadar artt\u0131\u2019 diyebilmek i\u00e7in ya\u015fa g\u00f6re ayr\u0131lm\u0131\u015f ulusal zaman-serisi verilerine ihtiya\u00e7 var. Elimizdeki en g\u00fcncel uluslararas\u0131 veri toplam vaka y\u00fck\u00fcn\u00fc g\u00f6steriyor; ya\u015f k\u0131r\u0131l\u0131m\u0131ndaki art\u0131\u015f\u0131n net oranlar\u0131n\u0131 s\u00f6ylemek i\u00e7in detayl\u0131 ulusal kay\u0131t analizleri gerekiyor. Bununla birlikte ya\u015fam<\/a> tarz\u0131 fakt\u00f6rleri; obezite, i\u015flenmi\u015f g\u0131da t\u00fcketimi, sedanter ya\u015fam, mikrobiyota de\u011fi\u015fiklikleri bu art\u0131\u015fta olas\u0131 rol oynuyor.\u201d<\/p>\n\n\n\n

Kolon Kanserini \u00d6nlemede En G\u00fc\u00e7l\u00fc Y\u00f6ntemler<\/strong><\/strong><\/p>\n\n\n\n

Yap\u0131lan yeni ke\u015ffin umut vadetti\u011finin alt\u0131n\u0131 \u00e7izen Yasin, \u201cBu, gelecekte \u00f6zellikle DNA hasar onar\u0131m yolaklar\u0131n\u0131 hedefleyen ila\u00e7larla kombinasyonlarda \u00f6nemli bir rol oynayabilir. Sonu\u00e7 olarak bilim her ge\u00e7en g\u00fcn ilerliyor, yeni hedefler ke\u015ffediliyor. Bug\u00fcn i\u00e7in kolon kanserinde en g\u00fc\u00e7l\u00fc silahlar\u0131m\u0131z\u0131n ise h\u00e2l\u00e2 \u015funlar oldu\u011funu s\u00f6yledi:<\/p>\n\n\n\n

–<\/strong> Tarama programlar\u0131na kat\u0131lmak
–<\/strong> 50 ya\u015f sonras\u0131 d\u00fczenli test yapt\u0131rmak
– Sa\u011fl\u0131kl\u0131 kilo, hareket ve liften zengin beslenme
–<\/strong> Sigara ve a\u015f\u0131r\u0131 i\u015flenmi\u015f g\u0131dadan ka\u00e7\u0131nmak<\/p>\n\n\n\n

14.03.2026 18:54<\/p>\n\n\n\n

Kaynak:https:\/\/www.hurriyet.com.tr\/aile\/bilim-insanlari-yeni-bir-tedavi-kesfetti-gencler-arasinda-yayilmaya-baslamisti-o-kanser-tarih-mi-oluyor-43120401<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Mart ay\u0131, d\u00fcnya genelinde Kolon Kanseri Fark\u0131ndal\u0131k Ay\u0131 olarak kabul ediliyor. \u00d6zellikle gen\u00e7ler aras\u0131nda giderek yayg\u0131nla\u015fan kolon kanseri \u00e7o\u011fu zaman sinsi ilerleyerek \u00f6l\u00fcmc\u00fcl olabiliyor. Ancak G\u00fcney Koreli bilim insanlar\u0131n\u0131n yapt\u0131\u011f\u0131 yeni bir ara\u015ft\u0131rma umut verdi. Ara\u015ft\u0131rmaya g\u00f6re, h\u00fccrelerdeki tek bir proteinin bloke edilmesi kolorektal (kal\u0131n ba\u011f\u0131rsak) kanserinin ilerlemesini durdurabilir ve ya\u015fam s\u00fcresini uzatabilir. \u0130\u015fte dikkat…<\/p>\n","protected":false},"author":4,"featured_media":2692,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[2],"tags":[256,1005,638],"class_list":["post-2691","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yasam","tag-kanser","tag-kolon","tag-tedavi"],"jetpack_featured_media_url":"https:\/\/dbsnewsmedia.com\/wp-content\/uploads\/2026\/03\/69b3d85d717271c959b2ee89.webp","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/2691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2691"}],"version-history":[{"count":1,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/2691\/revisions"}],"predecessor-version":[{"id":2693,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/2691\/revisions\/2693"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/media\/2692"}],"wp:attachment":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}