{"id":4492,"date":"2026-03-31T20:05:53","date_gmt":"2026-03-31T17:05:53","guid":{"rendered":"https:\/\/dbsnewsmedia.com\/?p=4492"},"modified":"2026-03-31T20:05:53","modified_gmt":"2026-03-31T17:05:53","slug":"genetik-sifredeki-beklenmedik-mobilite-hastaliklarin-kaynagi-cikti","status":"publish","type":"post","link":"https:\/\/dbsnewsmedia.com\/?p=4492","title":{"rendered":"Genetik \u015eifredeki Beklenmedik Mobilite Hastal\u0131klar\u0131n Kayna\u011f\u0131 \u00c7\u0131kt\u0131"},"content":{"rendered":"\n

31.03.2026 20:03<\/p>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar, genetik kodlar\u0131n muhafaza edildi\u011fi merkezde dura\u011fan bir yap\u0131n\u0131n aksine, aral\u0131ks\u0131z bir \u015fekilde \u201cbi\u00e7im de\u011fi\u015ftirme ve yay\u0131lma\u201d d\u00f6ng\u00fcs\u00fcn\u00fcn ya\u015fand\u0131\u011f\u0131n\u0131 saptad\u0131. Bu ya\u015famsal ak\u0131\u015f\u0131n sekteye u\u011framas\u0131n\u0131n, k\u00f6t\u00fc huylu t\u00fcm\u00f6r olu\u015fumlar\u0131 ile organizman\u0131n b\u00fcy\u00fcme aksakl\u0131klar\u0131n\u0131n as\u0131l tetikleyicisi olabilece\u011fi \u00f6ng\u00f6r\u00fcl\u00fcyor.<\/strong><\/p>\n\n\n\n

Y\u0131llard\u0131r genetik kodumuzu, h\u00fccrelerimizin \u00e7ekirde\u011finde sabit duran devasa bir k\u00fct\u00fcphane gibi hayal ettik. Ancak Salk Enstit\u00fcs\u00fc\u2019nden ara\u015ft\u0131rmac\u0131lar\u0131n yay\u0131mlad\u0131\u011f\u0131 yeni bir \u00e7al\u0131\u015fma, bu k\u00fct\u00fcphanenin asl\u0131nda s\u00fcrekli hareket eden, sayfalar\u0131 durmadan a\u00e7\u0131l\u0131p kapanan canl\u0131 bir yap\u0131 oldu\u011funu ortaya koyuyor.<\/p>\n\n\n\n

\u0130nsan genomu yakla\u015f\u0131k alt\u0131 milyar baz \u00e7iftinden olu\u015fur. Bu devasa verinin mikroskobik bir h\u00fccre \u00e7ekirde\u011fine s\u0131\u011fmas\u0131 i\u00e7in DNA\u2019n\u0131n karma\u015f\u0131k halkalar ve d\u00f6ng\u00fcler halinde katlanmas\u0131 gerekir.<\/p>\n\n\n\n

Nature Genetics<\/em> dergisinde yay\u0131mlanan \u00e7al\u0131\u015fmaya g\u00f6re, bu katlanma i\u015flemi bir kez olup bitmiyor.<\/p>\n\n\n\n

Cohesin ve NIPBL ad\u0131 verilen \u00f6zel proteinler, birer \u201cmolek\u00fcler makine\u201d gibi \u00e7al\u0131\u015farak DNA \u00fczerinde s\u00fcrekli yeni d\u00f6ng\u00fcler olu\u015fturuyor ve bunlar\u0131 bozuyor.<\/p>\n\n\n\n

Salk Enstit\u00fcs\u00fc\u2019nden Do\u00e7ent Jesse Dixon, durumu \u015f\u00f6yle a\u00e7\u0131kl\u0131yor:<\/p>\n\n\n\n

\u201c\u0130lgin\u00e7 olan, bu katlanman\u0131n bir kez ger\u00e7ekle\u015fip orada kalmamas\u0131. Genom s\u00fcrekli bir a\u00e7\u0131lma ve yeniden katlanma d\u00f6ng\u00fcs\u00fc i\u00e7inde. Bu hareket, hangi genlerin \u2018a\u00e7\u0131k\u2019 hangilerinin \u2018kapal\u0131\u2019 kalaca\u011f\u0131n\u0131 do\u011frudan belirliyor.\u201d<\/em><\/p>\n\n\n\n

Molek\u00fcler Devinim Organizman\u0131n Temel Karakterini Belirliyor<\/strong><\/p>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar, bu hareketlili\u011fin rastgele olmad\u0131\u011f\u0131n\u0131 fark etti. Kalp h\u00fccrelerinde kalple ilgili genler, n\u00f6ronlarda ise beyinle ilgili genler \u00e7ok daha h\u0131zl\u0131 ve dinamik bir \u015fekilde katlan\u0131yor. Bilim insanlar\u0131na g\u00f6re bu \u201chareketlilik\u201d, h\u00fccrenin kimli\u011fini korumas\u0131n\u0131 sa\u011fl\u0131yor.<\/p>\n\n\n\n

\u00c7al\u0131\u015fman\u0131n ba\u015fyazar\u0131 Dr. Tessa Popay, \u201cBu s\u00fcrekli hareket, h\u00fccrenin kim oldu\u011funu hat\u0131rlamas\u0131na yard\u0131mc\u0131 oluyor\u201d diyor. E\u011fer bu dans durursa veya ritmi bozulursa, h\u00fccre ne yapmas\u0131 gerekti\u011fini \u201cunutabiliyor\u201d ve bu da kontrols\u00fcz h\u00fccre b\u00fcy\u00fcmesine, yani kansere yol a\u00e7abiliyor.<\/p>\n\n\n\n

K\u00f6t\u00fc Huylu H\u00fccrelerin S\u0131rr\u0131 \u00c7\u00f6z\u00fcl\u00fcyor: Biyolojik Devinimdeki Hayati \u00d6ncelik<\/strong><\/p>\n\n\n\n

Mevcut kanser tedavilerinin \u00e7o\u011fu genetik mutasyonlara (kodun kendisindeki hatalara) odaklan\u0131yor. Ancak bu \u00e7al\u0131\u015fma, kodun kendisi sa\u011flam olsa bile katlanma bi\u00e7imindeki bir hatan\u0131n hastal\u0131\u011f\u0131 tetikleyebilece\u011fini g\u00f6steriyor.<\/p>\n\n\n\n

Dixon ve ekibi, kanserin bu katlanma mekanizmalar\u0131n\u0131 suistimal ederek h\u00fccre kimli\u011fini manip\u00fcle etti\u011fini ve kontrols\u00fcz b\u00fcy\u00fcmeyi te\u015fvik etti\u011fini d\u00fc\u015f\u00fcn\u00fcyor. Bu dinamikleri anlamak, gelecekte sadece genleri de\u011fil, DNA\u2019n\u0131n hatal\u0131 katlanma bi\u00e7imlerini d\u00fczeltecek yeni tedavi y\u00f6ntemlerinin geli\u015ftirilmesini sa\u011flayabilir.<\/p>\n\n\n\n

Karde\u015f haber kaynak:https:\/\/checkinhaber.com\/2026\/03\/31\/genetik-sifredeki-beklenmedik-mobilite-hastaliklarin-kaynagi-cikti\/<\/a><\/p>\n\n\n\n

G\u00f6rsel Kaynak: https:\/\/i.gazeteoksijen.com\/2\/850\/478\/storage\/files\/images\/2025\/07\/24\/dunya-kansere-karsi-savasi-kazaniyor-lf2f.jpg<\/a><\/p>\n\n\n\n

Kaynak: https:\/\/gazeteoksijen.com\/saglik\/kanser-tedavisinde-cigir-acabilir-dnanin-hareket-ettigi-kesfedildi-270593<\/a><\/p>\n\n\n\n

https:\/\/gazeteoksijen.com\/saglik<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

31.03.2026 20:03 Ara\u015ft\u0131rmac\u0131lar, genetik kodlar\u0131n muhafaza edildi\u011fi merkezde dura\u011fan bir yap\u0131n\u0131n aksine, aral\u0131ks\u0131z bir \u015fekilde \u201cbi\u00e7im de\u011fi\u015ftirme ve yay\u0131lma\u201d d\u00f6ng\u00fcs\u00fcn\u00fcn ya\u015fand\u0131\u011f\u0131n\u0131 saptad\u0131. Bu ya\u015famsal ak\u0131\u015f\u0131n sekteye u\u011framas\u0131n\u0131n, k\u00f6t\u00fc huylu t\u00fcm\u00f6r olu\u015fumlar\u0131 ile organizman\u0131n b\u00fcy\u00fcme aksakl\u0131klar\u0131n\u0131n as\u0131l tetikleyicisi olabilece\u011fi \u00f6ng\u00f6r\u00fcl\u00fcyor. Y\u0131llard\u0131r genetik kodumuzu, h\u00fccrelerimizin \u00e7ekirde\u011finde sabit duran devasa bir k\u00fct\u00fcphane gibi hayal ettik. Ancak Salk Enstit\u00fcs\u00fc\u2019nden…<\/p>\n","protected":false},"author":5,"featured_media":4493,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[12],"tags":[1543],"class_list":["post-4492","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-genetik-sifre"],"jetpack_featured_media_url":"https:\/\/dbsnewsmedia.com\/wp-content\/uploads\/2026\/03\/47-2.webp","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/4492","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4492"}],"version-history":[{"count":1,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/4492\/revisions"}],"predecessor-version":[{"id":4494,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/4492\/revisions\/4494"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/media\/4493"}],"wp:attachment":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4492"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4492"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4492"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}