{"id":6552,"date":"2026-04-18T15:31:10","date_gmt":"2026-04-18T12:31:10","guid":{"rendered":"https:\/\/dbsnewsmedia.com\/?p=6552"},"modified":"2026-04-18T15:31:10","modified_gmt":"2026-04-18T12:31:10","slug":"bilim-dunyasi-ikiye-bolundu-alzheimerda-amiloid-tartismasi-derinlesiyor","status":"publish","type":"post","link":"https:\/\/dbsnewsmedia.com\/?p=6552","title":{"rendered":"Bilim D\u00fcnyas\u0131 \u0130kiye B\u00f6l\u00fcnd\u00fc: Alzheimer\u2019da Amiloid Tart\u0131\u015fmas\u0131 Derinle\u015fiyor"},"content":{"rendered":"\n

Alzheimer tedavisinde devrim olarak tan\u0131t\u0131lan amiloid hedefli ila\u00e7lar\u0131n, klinik a\u00e7\u0131dan anlaml\u0131 bir fayda sa\u011flamad\u0131\u011f\u0131 ortaya kondu. Bu bulgular\u0131n ard\u0131ndan uzmanlar aras\u0131nda \u201cbo\u015fa umut\u201d ve \u201cbilimsel g\u00fcr\u00fclt\u00fc\u201d tart\u0131\u015fmas\u0131 yeniden alevlendi.<\/strong><\/p>\n\n\n\n

D\u00fcnya genelinde h\u0131zla artan Alzheimer <\/strong>vakalar\u0131na kar\u015f\u0131 geli\u015ftirilen ve beyindeki protein plaklar\u0131n\u0131 temizlemeyi ama\u00e7layan yeni nesil ila\u00e7lar, bilimsel bir yol ayr\u0131m\u0131nda. 2026 y\u0131l\u0131 sa\u011fl\u0131k verilerine g\u00f6re demans<\/strong>, k\u00fcresel bir halk sa\u011fl\u0131\u011f\u0131 krizi olma yolunda ilerlerken, en prestijli t\u0131bbi inceleme kurulu\u015flar\u0131ndan biri olan Cochrane<\/strong>‘den sars\u0131c\u0131 bir rapor geldi. 17 klinik deneyi ve 20 binden fazla hastay\u0131 kapsayan analiz; aducanumab<\/strong>, donanemab <\/strong>ve lecanemab <\/strong>gibi \u00e7ok konu\u015fulan ila\u00e7lar\u0131n, beyindeki amiloid <\/strong>plaklar\u0131n\u0131 temizlemesine ra\u011fmen hastalar\u0131n g\u00fcnl\u00fck ya\u015fam kalitesinde ve bili\u015fsel yetilerinde “anlaml\u0131 bir iyile\u015fme” yaratmad\u0131\u011f\u0131n\u0131 saptad\u0131.<\/p>\n\n\n\n

Veriler G\u00fc\u00e7l\u00fc, Etki Zay\u0131f: Klinik Fayda Sorgulan\u0131yor<\/h3>\n\n\n\n

\u0130ncelemenin ba\u015fyazar\u0131 n\u00f6rolog ve epidemiyolog Francesco Nonino, ara\u015ft\u0131rman\u0131n sonu\u00e7lar\u0131n\u0131 “ikna edici” olarak nitelendirdi. Nonino, yap\u0131lan deneylerde istatistiksel olarak bir fark g\u00f6r\u00fclse de, bunun hastan\u0131n ger\u00e7ek hayat\u0131na yans\u0131yan klinik bir kar\u015f\u0131l\u0131\u011f\u0131 olmad\u0131\u011f\u0131n\u0131 vurgulad\u0131. Raporda, beyindeki amiloid proteinlerinin temizlenmesinin Alzheimer semptomlar\u0131n\u0131 durdurmaya yetmedi\u011fi, bu nedenle bilim d\u00fcnyas\u0131n\u0131n art\u0131k farkl\u0131 biyolojik mekanizmalara odaklanmas\u0131 gerekti\u011fi ifade edildi. University College London’dan Profes\u00f6r Robert Howard ise sonu\u00e7lar\u0131n s\u00fcrpriz olmad\u0131\u011f\u0131n\u0131 belirterek, bu tedavilerin ailelere “a\u015f\u0131r\u0131 iyimser” ve “bilimsel olarak desteklenmeyen” bir \u015fekilde sunulmas\u0131n\u0131n sahte umutlar yaratt\u0131\u011f\u0131na dikkat \u00e7ekti.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Uzmanlar Ayr\u0131\u015ft\u0131: \u201c\u0130statistiksel G\u00fcr\u00fclt\u00fc\u201d Tart\u0131\u015fmas\u0131 B\u00fcy\u00fcyor<\/h3>\n\n\n\n

Ancak Cochrane raporunun sonu\u00e7lar\u0131na her kesimden destek gelmiyor. Baz\u0131 ara\u015ft\u0131rmac\u0131lar, incelemenin y\u00f6ntemindeki “genellemeye” kar\u015f\u0131 \u00e7\u0131k\u0131yor. Birle\u015fik Krall\u0131k Demans Ara\u015ft\u0131rma Enstit\u00fcs\u00fc’nden Bart De Strooper, incelemenin ilk nesil ba\u015far\u0131s\u0131z ila\u00e7larla, umut vaat eden yeni nesil tedavileri ayn\u0131 havuzda toplamas\u0131n\u0131 “temel bir kusur” olarak nitelendirdi. De Strooper, “Bu inceleme kan\u0131tlar\u0131 netle\u015ftirmek yerine bulan\u0131kla\u015ft\u0131r\u0131yor; ba\u015far\u0131l\u0131 antikorlar\u0131 ba\u015far\u0131s\u0131z olanlarla kar\u0131\u015ft\u0131rarak terap\u00f6tik ilerlemeyi istatistiksel bir g\u00fcr\u00fclt\u00fcye d\u00f6n\u00fc\u015ft\u00fcr\u00fcyor” <\/em>dedi. Uzmanlara g\u00f6re, amiloid kar\u015f\u0131t\u0131 tedavilerden tamamen uzakla\u015fmak, on y\u0131llard\u0131r s\u00fcren \u00f6nc\u00fc \u00e7al\u0131\u015fmalar\u0131 \u00e7\u00f6pe atmak anlam\u0131na gelebilir.<\/p>\n\n\n\n

Tedavide Yan Etki ve Maliyet Engeli<\/h3>\n\n\n\n

Tart\u0131\u015fman\u0131n oda\u011f\u0131nda sadece etkinlik de\u011fil, ayn\u0131 zamanda g\u00fcvenlik ve maliyet de bulunuyor. S\u00f6z konusu ila\u00e7lar\u0131n klinik deneylerinde baz\u0131 hastalarda \u00f6l\u00fcmc\u00fcl olabilen beyin kanamas\u0131 ve beyin \u00f6demi gibi yan etkiler saptanm\u0131\u015ft\u0131. Bu durum, Birle\u015fik Krall\u0131k Ulusal Sa\u011fl\u0131k ve Bak\u0131m M\u00fckemmelli\u011fi Enstit\u00fcs\u00fc’n\u00fcn (NICE), bu ila\u00e7lar\u0131n maliyet-fayda dengesini kar\u015f\u0131lamad\u0131\u011f\u0131 gerek\u00e7esiyle kamu sa\u011fl\u0131\u011f\u0131 sistemine dahil edilmemesi karar\u0131yla sonu\u00e7lanm\u0131\u015ft\u0131. ABD ve Birle\u015fik Krall\u0131k’ta \u00f6zel sa\u011fl\u0131k hizmetleri arac\u0131l\u0131\u011f\u0131yla eri\u015filebilen bu tedavilerin gelece\u011fi, devam eden yeni klinik deneylerin sonu\u00e7lar\u0131na g\u00f6re \u015fekillenecek.<\/p>\n\n\n\n

18.04.2026 15:30<\/p>\n\n\n\n

Kaynak:https:\/\/www.cumhuriyet.com.tr\/yasam\/alzheimer-tedavisinde-amiloid-tartismasi-altin-standart-incelemede-carpici-sonuc-2496259<\/a><\/p>\n\n\n\n

G\u00f6rseller Pexels.com’dan al\u0131nm\u0131\u015ft\u0131r.<\/em><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Alzheimer tedavisinde devrim olarak tan\u0131t\u0131lan amiloid hedefli ila\u00e7lar\u0131n, klinik a\u00e7\u0131dan anlaml\u0131 bir fayda sa\u011flamad\u0131\u011f\u0131 ortaya kondu. Bu bulgular\u0131n ard\u0131ndan uzmanlar aras\u0131nda \u201cbo\u015fa umut\u201d ve \u201cbilimsel g\u00fcr\u00fclt\u00fc\u201d tart\u0131\u015fmas\u0131 yeniden alevlendi. D\u00fcnya genelinde h\u0131zla artan Alzheimer vakalar\u0131na kar\u015f\u0131 geli\u015ftirilen ve beyindeki protein plaklar\u0131n\u0131 temizlemeyi ama\u00e7layan yeni nesil ila\u00e7lar, bilimsel bir yol ayr\u0131m\u0131nda. 2026 y\u0131l\u0131 sa\u011fl\u0131k verilerine g\u00f6re demans, k\u00fcresel bir…<\/p>\n","protected":false},"author":4,"featured_media":6554,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[2],"tags":[1030,413],"class_list":["post-6552","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yasam","tag-alzheimer","tag-yaslilik"],"jetpack_featured_media_url":"https:\/\/dbsnewsmedia.com\/wp-content\/uploads\/2026\/04\/pexels-olly-3921418-scaled.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/6552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6552"}],"version-history":[{"count":1,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/6552\/revisions"}],"predecessor-version":[{"id":6555,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/6552\/revisions\/6555"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/media\/6554"}],"wp:attachment":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}