{"id":6826,"date":"2026-04-20T21:07:16","date_gmt":"2026-04-20T18:07:16","guid":{"rendered":"https:\/\/dbsnewsmedia.com\/?p=6826"},"modified":"2026-04-20T21:07:16","modified_gmt":"2026-04-20T18:07:16","slug":"rejeneratif-tipta-cigir-acan-kesif-akcigeri-iyilestiren-molekuler-kelepce-cozuldu","status":"publish","type":"post","link":"https:\/\/dbsnewsmedia.com\/?p=6826","title":{"rendered":"Rejeneratif T\u0131pta \u00c7\u0131\u011f\u0131r A\u00e7an Ke\u015fif: Akci\u011feri \u0130yile\u015ftiren \u201cMolek\u00fcler Kelep\u00e7e\u201d \u00c7\u00f6z\u00fcld\u00fc!"},"content":{"rendered":"\n

20.04.2026 21:09<\/p>\n\n\n\n

Mayo Clinic b\u00fcnyesinde \u00e7al\u0131\u015fan bilim insanlar\u0131, akci\u011fer fibrozisi, KOAH ve Covid-19 gibi a\u011f\u0131r hastal\u0131klar\u0131n neden akci\u011ferde kal\u0131c\u0131 hasar b\u0131rakt\u0131\u011f\u0131na dair on y\u0131llard\u0131r s\u00fcregelen gizemi \u00e7\u00f6zd\u00fc. Nature Communications<\/em> dergisinde yay\u0131mlanan tarihi \u00e7al\u0131\u015fmaya g\u00f6re; akci\u011fer h\u00fccrelerinin \u201cdoku hasar\u0131n\u0131 onarmak\u201d ile \u201cenfeksiyonla sava\u015fmak\u201d aras\u0131nda nas\u0131l bir se\u00e7im yapt\u0131\u011f\u0131n\u0131 belirleyen molek\u00fcler bir \u201ca\u00e7ma-kapama d\u00fc\u011fmesi\u201d ke\u015ffedildi. Uzmanlar, bu molek\u00fcler anahtara m\u00fcdahale ederek kronikle\u015fmi\u015f solunum hastal\u0131klar\u0131n\u0131 geriye \u00e7evirebilme (rejenerasyon) potansiyelinin kap\u0131s\u0131n\u0131 aralad\u0131.<\/strong><\/p>\n\n\n\n

Ara\u015ft\u0131rman\u0131n k\u0131demli yazar\u0131 Dr. Douglas Brownfield\u2019\u0131n tespitlerine g\u00f6re sorunun temelinde, akci\u011fer h\u00fccrelerinin ayn\u0131 anda \u201ciki i\u015fi birden yapamamas\u0131\u201d yat\u0131yor. H\u00fccrelerin bir k\u0131sm\u0131 enfeksiyona kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k savunmas\u0131n\u0131 \u00fcstlenirken, di\u011ferleri doku onar\u0131m\u0131na odaklanmak zorunda. Ancak a\u011f\u0131r enfeksiyonlarda bu h\u00fccresel i\u015f b\u00f6l\u00fcm\u00fc \u00e7\u00f6k\u00fcyor, sistem tamamen \u201csavunma moduna\u201d kilitleniyor ve hasarl\u0131 doku kendini yenileyemiyor.<\/p>\n\n\n\n

Alveol Tip 2 (AT2) H\u00fccrelerinin Biyolojik Rol\u00fc<\/h3>\n\n\n\n

Ke\u015ffin merkezinde, akci\u011ferin \u201cyedek k\u00f6k h\u00fccreleri\u201d olarak bilinen Alveol Tip 2 (AT2)<\/strong> h\u00fccreleri yer al\u0131yor. Bu h\u00fccreler, normal \u015fartlarda nefes al\u0131p verirken hava keseciklerinin (alveollerin) a\u00e7\u0131k kalmas\u0131n\u0131 sa\u011flayan s\u00fcrfaktan proteinlerini \u00fcretir. Daha da \u00f6nemlisi, akci\u011ferde bir hasar olu\u015ftu\u011funda bu AT2 h\u00fccreleri; do\u011frudan oksijenin kana kar\u0131\u015ft\u0131\u011f\u0131 gaz al\u0131\u015fveri\u015f y\u00fczeyini olu\u015fturan Alveol Tip 1 (AT1)<\/strong> h\u00fccrelerine d\u00f6n\u00fc\u015ferek (h\u00fccresel farkl\u0131la\u015fma) dokuyu onarma kapasitesine sahiptir.<\/p>\n\n\n\n

C\/EBP\u03b1: K\u00f6k H\u00fccreyi Tutan \u201cMolek\u00fcler Kelep\u00e7e\u201d<\/h3>\n\n\n\n

H\u00fccrelerin \u201cya\u015fam d\u00f6ng\u00fcs\u00fcn\u00fc\u201d tek h\u00fccre dizileme (single-cell sequencing) ve g\u00f6r\u00fcnt\u00fcleme y\u00f6ntemleriyle inceleyen ekip, AT2 h\u00fccrelerinin onar\u0131m s\u00fcrecine ge\u00e7i\u015fini y\u00f6neten \u00fc\u00e7 ana genetik unsuru tespit etti: PRC2, DLK1 ve C\/EBP\u03b1<\/strong>.<\/p>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar \u00f6zellikle C\/EBP\u03b1<\/strong> molek\u00fcl\u00fcn\u00fc, k\u00f6k h\u00fccrenin onar\u0131m yapmas\u0131n\u0131 engelleyen \u201ctutuklay\u0131c\u0131 bir kelep\u00e7e\u201d<\/em> olarak tan\u0131ml\u0131yor. Bir enfeksiyon an\u0131nda h\u00fccreler savunmaya odakland\u0131\u011f\u0131nda bu kelep\u00e7e kilitleniyor ve doku onar\u0131m\u0131 (rejenerasyon) tamamen duruyor. Laboratuvar ortam\u0131nda geli\u015ftirilecek yeni nesil ila\u00e7lar\u0131n ana hedefi, bu \u201ck\u0131s\u0131tlay\u0131c\u0131 kelep\u00e7eyi\u201d g\u00fcvenli bir \u015fekilde gev\u015feterek AT2 h\u00fccrelerinin akci\u011fer dokusunu yeniden in\u015fa etmesini (skarla\u015fmay\u0131 \u00f6nlemesini) sa\u011flamak olacak.<\/p>\n\n\n\n

Klinik Gelecek: Kronikle\u015fme S\u00fcrecini Geriye \u00c7evirmek<\/h3>\n\n\n\n

Ke\u015ffin onkoloji ve g\u00f6\u011f\u00fcs hastal\u0131klar\u0131 alan\u0131ndaki yans\u0131malar\u0131n\u0131 de\u011ferlendiren G\u00f6\u011f\u00fcs Hastal\u0131klar\u0131 Uzman\u0131 Dr. Banu Altoparlak, rejeneratif t\u0131bb\u0131n gelece\u011fi i\u00e7in \u015fu \u00e7arp\u0131c\u0131 tespitlerde bulunuyor:<\/p>\n\n\n\n

\n

\u201cBu yeni biyokimyasal m\u00fcdahale y\u00f6nteminin en b\u00fcy\u00fck avantaj\u0131; \u00f6zellikle kronik solunum yetmezli\u011fine yol a\u00e7an interstisyel akci\u011fer hastal\u0131klar\u0131, parankimal dokuyu etkileyen a\u011f\u0131r tablolar ve amfizemat\u00f6z (hava keseciklerinin par\u00e7aland\u0131\u011f\u0131) akci\u011fer hastal\u0131klar\u0131nda kronikle\u015fme s\u00fcrecini geriye \u00e7evirebilme potansiyelidir. Ama\u00e7, h\u00fccredeki biyobelirte\u00e7leri \u00f6nceden saptayarak hastalar geri d\u00f6n\u00fclmez bir solunum yetmezli\u011fine girmeden s\u00fcreci onar\u0131m moduna ge\u00e7irmektir.\u201d<\/em><\/p>\n<\/blockquote>\n\n\n\n

Bununla birlikte Dr. Altoparlak, laboratuvarda \u00e7o\u011falt\u0131lacak bu t\u00fcr yeni nesil h\u00fccre tedavilerinin tam anlam\u0131yla standart bir tedavi protokol\u00fcne d\u00f6n\u00fc\u015febilmesi i\u00e7in \u00f6ncelikle 10-15 y\u0131l s\u00fcrecek a\u011f\u0131r klinik (Faz) deneylerinden ge\u00e7mesi gerekti\u011fini hat\u0131rlat\u0131yor.<\/p>\n\n\n\n

Edit\u00f6r Notu: Bu i\u00e7erik, toplumu bilgilendirme amac\u0131yla akademik bir \u00e7al\u0131\u015fma kapsam\u0131nda yeniden derlenmi\u015ftir.<\/p>\n\n\n\n

Karde\u015f haber kaynak:http:\/\/yalingundem.com.tr\/rejeneratif-tipta-cigir-acan-kesif-akcigeri-iyilestiren-molekuler-kelepce-cozuldu\/<\/a><\/p>\n\n\n\n

Kaynak:https:\/\/www.hurriyet.com.tr\/aile\/akcigerde-cigir-acan-kesif-hucrelerin-onarim-dugmesi-bulundu-sureci-tersine-cevirebilme-potansiyeli-tasiyor-43115379<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

20.04.2026 21:09 Mayo Clinic b\u00fcnyesinde \u00e7al\u0131\u015fan bilim insanlar\u0131, akci\u011fer fibrozisi, KOAH ve Covid-19 gibi a\u011f\u0131r hastal\u0131klar\u0131n neden akci\u011ferde kal\u0131c\u0131 hasar b\u0131rakt\u0131\u011f\u0131na dair on y\u0131llard\u0131r s\u00fcregelen gizemi \u00e7\u00f6zd\u00fc. Nature Communications dergisinde yay\u0131mlanan tarihi \u00e7al\u0131\u015fmaya g\u00f6re; akci\u011fer h\u00fccrelerinin \u201cdoku hasar\u0131n\u0131 onarmak\u201d ile \u201cenfeksiyonla sava\u015fmak\u201d aras\u0131nda nas\u0131l bir se\u00e7im yapt\u0131\u011f\u0131n\u0131 belirleyen molek\u00fcler bir \u201ca\u00e7ma-kapama d\u00fc\u011fmesi\u201d ke\u015ffedildi. Uzmanlar, bu molek\u00fcler anahtara…<\/p>\n","protected":false},"author":5,"featured_media":6827,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[12],"tags":[2115],"class_list":["post-6826","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-molekuler-kelepce"],"jetpack_featured_media_url":"https:\/\/dbsnewsmedia.com\/wp-content\/uploads\/2026\/04\/37.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/6826","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6826"}],"version-history":[{"count":1,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/6826\/revisions"}],"predecessor-version":[{"id":6828,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/6826\/revisions\/6828"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/media\/6827"}],"wp:attachment":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}