{"id":7012,"date":"2026-04-22T19:26:50","date_gmt":"2026-04-22T16:26:50","guid":{"rendered":"https:\/\/dbsnewsmedia.com\/?p=7012"},"modified":"2026-04-22T19:26:50","modified_gmt":"2026-04-22T16:26:50","slug":"psikiyatride-farmakolojik-kabus-antidepresan-kaynakli-toksik-epidermal-nekroliz-vakalari-artiyor","status":"publish","type":"post","link":"https:\/\/dbsnewsmedia.com\/?p=7012","title":{"rendered":"Psikiyatride Farmakolojik Kabus: Antidepresan Kaynakl\u0131 \u201cToksik Epidermal Nekroliz\u201d Vakalar\u0131 Art\u0131yor!"},"content":{"rendered":"\n<p>22.04.2026   19:26<\/p>\n\n\n\n<p><strong>Depresyon tedavisinde kullan\u0131lan baz\u0131 ila\u00e7lar\u0131n etken maddeleri, hastalar\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde nadir g\u00f6r\u00fclen ancak son derece \u00f6l\u00fcmc\u00fcl olan \u201cToksik Epidermal Nekroliz (TEN)\u201d reaksiyonunu tetikleyebiliyor. H\u00fcrriyet Aile\u2019de yay\u0131mlanan g\u00fcncel t\u0131bbi vaka raporlar\u0131na g\u00f6re; Brezilya ve ABD\u2019de ayn\u0131 etken maddeyi kullanan iki kad\u0131n hastan\u0131n cildi, bu a\u011f\u0131r farmakolojik reaksiyon nedeniyle adeta \u201ca\u011f\u0131r yan\u0131k\u201d tablosuna d\u00f6n\u00fc\u015ferek tamamen soyuldu. Uzmanlar, s\u0131radan bir d\u00f6k\u00fcnt\u00fc gibi ba\u015flayan ancak saatler i\u00e7inde i\u00e7 organlar\u0131 ve mukoza zarlar\u0131n\u0131 par\u00e7alayan bu otoimm\u00fcn krize kar\u015f\u0131 hastalar\u0131 ve hekimleri acil m\u00fcdahale konusunda uyar\u0131yor.<\/strong><\/p>\n\n\n\n<p>T\u0131p literat\u00fcr\u00fcnde genellikle epilepsi ila\u00e7lar\u0131 ve a\u011f\u0131r antibiyotiklerle ili\u015fkilendirilen TEN (cildin \u00fcst tabakas\u0131n\u0131n nekroza u\u011frayarak \u00f6lmesi ve d\u00f6k\u00fclmesi) sendromunun, psikiyatrik tedavilerde (antidepresan kullan\u0131m\u0131nda) de ortaya \u00e7\u0131kmas\u0131 t\u0131p camias\u0131nda ciddi bir endi\u015fe yaratt\u0131.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Vaka 1: Sao Paulo\u2019da 66 G\u00fcnl\u00fck Ya\u015fam Sava\u015f\u0131<\/h3>\n\n\n\n<p>Brezilya\u2019n\u0131n Sao Paulo kentindeki Hospital Beneficencia Portuguesa\u2019da tedavi alt\u0131na al\u0131nan 42 ya\u015f\u0131ndaki kad\u0131n hastan\u0131n klinik tablosu, sendromun y\u0131k\u0131c\u0131 h\u0131z\u0131n\u0131 g\u00f6zler \u00f6n\u00fcne seriyor:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Kulu\u00e7ka ve Ba\u015flang\u0131\u00e7:<\/strong>\u00a0\u0130lac\u0131 kullanmaya ba\u015flad\u0131ktan tam 3 hafta sonra ilk belirtiler (hafif k\u0131zar\u0131kl\u0131klar) g\u00f6r\u00fcld\u00fc. Ancak tablo saatler i\u00e7inde y\u00fcz, ba\u015f, boyun ve g\u00f6vde b\u00f6lgesine yay\u0131lan a\u00e7\u0131k lezyonlara d\u00f6n\u00fc\u015ft\u00fc.<\/li>\n\n\n\n<li><strong>Klinik Y\u0131k\u0131m:<\/strong>\u00a0Hastaneye kabul\u00fcn\u00fcn ikinci g\u00fcn\u00fcnde cilt tamamen koyu mora d\u00f6nerek soyulmaya ba\u015flad\u0131. D\u00f6rd\u00fcnc\u00fc g\u00fcnde ise \u00f6zellikle a\u011f\u0131z \u00e7evresindeki deri siyaha yakla\u015ft\u0131 ve g\u00f6r\u00fcn\u00fcm 3. derece a\u011f\u0131r bir yan\u0131k vakas\u0131n\u0131 and\u0131r\u0131yordu.<\/li>\n\n\n\n<li><strong>Yo\u011fun Bak\u0131m ve Biyomateryal Tedavisi:<\/strong>\u00a0Derhal yo\u011fun bak\u0131ma al\u0131nan hastaya agresif bir antibiyotik protokol\u00fc uyguland\u0131 ve doku iyile\u015fmesini desteklemek i\u00e7in y\u00fcz\u00fcne \u201cantibakteriyel biyomateryal\u201d greftleri yerle\u015ftirildi.<\/li>\n\n\n\n<li><strong>Toparlanma:<\/strong>\u00a066 g\u00fcn s\u00fcren zorlu ya\u015fam sava\u015f\u0131n\u0131n ard\u0131ndan cilt yava\u015f yava\u015f kendini yeniledi. 6\u2019nc\u0131 ay\u0131n sonundaki klinik kontrolde doku onar\u0131m\u0131 \u201cm\u00fckemmel\u201d olarak raporland\u0131.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Vaka 2: ABD\u2019de G\u00f6rme Kayb\u0131yla Biten Trajedi<\/h3>\n\n\n\n<p>Ayn\u0131 antidepresan etken maddesine ba\u011fl\u0131 bir di\u011fer vaka ise ABD\u2019nin Chicago kentinde raporland\u0131. Bu vaka, erken m\u00fcdahale edilmeyen reaksiyonlar\u0131n ne kadar kal\u0131c\u0131 hasarlar b\u0131rakabilece\u011fini kan\u0131tl\u0131yor:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>H\u0131zl\u0131 \u0130lerleme:<\/strong>\u00a0\u0130la\u00e7 kullan\u0131m\u0131n\u0131n 16. g\u00fcn\u00fcnde g\u00f6zlerde kuruluk ve dudaklarda \u015fi\u015fme ile ba\u015flayan reaksiyon, ikinci g\u00fcnde nefes darl\u0131\u011f\u0131, a\u011f\u0131r konf\u00fczyon (zihin bulan\u0131kl\u0131\u011f\u0131) ve y\u00f6nelim bozuklu\u011funa evrildi.<\/li>\n\n\n\n<li><strong>Yan\u0131k \u00dcnitesi:<\/strong>\u00a0T\u00fcm v\u00fccudu kabarc\u0131klarla kaplanan hasta, tam 7 hafta boyunca yan\u0131k \u00fcnitesinde izole bir \u015fekilde tedavi g\u00f6rd\u00fc.<\/li>\n\n\n\n<li><strong>Kal\u0131c\u0131 Hasar:<\/strong>\u00a0Hasta hayatta kalmay\u0131 ba\u015farsa da; v\u00fccudundaki cildin b\u00fcy\u00fck bir b\u00f6l\u00fcm\u00fcn\u00fc kaybetti, g\u00f6z kapaklar\u0131n\u0131n yeniden in\u015fas\u0131 i\u00e7in say\u0131s\u0131z rekonstr\u00fcktif cerrahi ge\u00e7irdi ve en ac\u0131s\u0131\u00a0<strong>kal\u0131c\u0131 g\u00f6rme kayb\u0131<\/strong>\u00a0ya\u015fad\u0131.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Uzmanlardan Kritik \u201cMukoza\u201d Uyar\u0131s\u0131<\/h3>\n\n\n\n<p>Farmakologlar ve dermatologlar, yeni ba\u015flanan herhangi bir ila\u00e7 tedavisinin ard\u0131ndan s\u0131radan gibi g\u00f6r\u00fcnen d\u00f6k\u00fcnt\u00fclerin asla hafife al\u0131nmamas\u0131 gerekti\u011fini vurguluyor. D\u00f6k\u00fcnt\u00fclere&nbsp;<strong>a\u011f\u0131z i\u00e7i yaralar, g\u00f6zlerde kanlanma\/k\u0131zar\u0131kl\u0131k, dudak \u015fi\u015fmesi veya solunum s\u0131k\u0131nt\u0131s\u0131<\/strong>&nbsp;(mukoza tutulumu) e\u015flik ediyorsa, bu durum basit bir alerji de\u011fil, \u00f6l\u00fcmc\u00fcl bir \u201cToksik Epidermal Nekroliz\u201d ba\u015flang\u0131c\u0131 olabilir. Bu noktada saniyeler bile hayati \u00f6nem ta\u015f\u0131r.<\/p>\n\n\n\n<p>Edit\u00f6r Notu: Bu i\u00e7erik, toplumu bilgilendirme amac\u0131yla akademik bir \u00e7al\u0131\u015fma kapsam\u0131nda yeniden derlenmi\u015ftir.<\/p>\n\n\n\n<p>Karde\u015f haber kaynak:<a href=\"http:\/\/yalingundem.com.tr\/psikiyatride-farmakolojik-kabus-antidepresan-kaynakli-toksik-epidermal-nekroliz-vakalari-artiyor\/\">http:\/\/yalingundem.com.tr\/psikiyatride-farmakolojik-kabus-antidepresan-kaynakli-toksik-epidermal-nekroliz-vakalari-artiyor\/<\/a><br>Kaynak:<a href=\"https:\/\/www.hurriyet.com.tr\/aile\/galeri-depresyon-ilaci-kabusu-yuzu-taninmaz-hale-geldi-66-gun-hastanede-kaldi-43155054\/2\">https:\/\/www.hurriyet.com.tr\/aile\/galeri-depresyon-ilaci-kabusu-yuzu-taninmaz-hale-geldi-66-gun-hastanede-kaldi-43155054\/2<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>22.04.2026 19:26 Depresyon tedavisinde kullan\u0131lan baz\u0131 ila\u00e7lar\u0131n etken maddeleri, hastalar\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde nadir g\u00f6r\u00fclen ancak son derece \u00f6l\u00fcmc\u00fcl olan \u201cToksik Epidermal Nekroliz (TEN)\u201d reaksiyonunu tetikleyebiliyor. H\u00fcrriyet Aile\u2019de yay\u0131mlanan g\u00fcncel t\u0131bbi vaka raporlar\u0131na g\u00f6re; Brezilya ve ABD\u2019de ayn\u0131 etken maddeyi kullanan iki kad\u0131n hastan\u0131n cildi, bu a\u011f\u0131r farmakolojik reaksiyon nedeniyle adeta \u201ca\u011f\u0131r yan\u0131k\u201d tablosuna d\u00f6n\u00fc\u015ferek tamamen&#8230;<\/p>\n","protected":false},"author":5,"featured_media":7013,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[2206],"class_list":["post-7012","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genel","tag-antidepresan"],"jetpack_featured_media_url":"https:\/\/dbsnewsmedia.com\/wp-content\/uploads\/2026\/04\/62.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/7012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7012"}],"version-history":[{"count":1,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/7012\/revisions"}],"predecessor-version":[{"id":7014,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/posts\/7012\/revisions\/7014"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=\/wp\/v2\/media\/7013"}],"wp:attachment":[{"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dbsnewsmedia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}